Franklin

DNA, words and models / Stéphane Robin, François Rodolphe, Sophie Schbath.

Author/Creator:
Robin, Stéphane, 1965-
Standardized Title:
ADN, mots, et modéles. English
Publication:
Cambridge, UK ; New York : Cambridge University Press, 2005.
Format/Description:
Book
xx, 138 p. : ill. ; 24 cm.
Subjects:
Genetics -- Mathematical models.
Markov processes.
Contents:
1. Introduction:
The context
Randomness and models
A bit of biology

Simple models for biological sequences:
Why a model?
Permutation model
Bernoulli model

Introduction to Markov chain models:
Assumptions
Markov chain order 1
Markov chain order m
Estimation of the parameters

Taking heterogeneities into account:
Phased chains
Piecewise homogeneous Markov chains
Translation conditional models

Statistical properties of word occurrences:
Count
Positions and distances
Distribution along the sequence

Words with unexpected frequencies:
Exact distribution and approximations
Influence of the model
Over-representations of Chi sites in E. coli and H. influenzae
Under-representation of palindromes of length 6 in E. coli and in the phage Lambda

Words with unexpected locations:
Chi sites in the genome of H. influenzae
Distribution of palindromes in E. coli's genome
Detection of promoter sites in B. subtilis

The last word.
Notes:
Includes bibliographical references (p. 134-136) and index.
Contributor:
Rodolphe, François.
Schbath, Sophie, 1969-
ISBN:
052184729X (hbk.)
OCLC:
60311992
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