Franklin

Protein kinase C in cancer Signaling and therapy [electronic resource] / edited by Marcelo G. Kazanietz.

Publication:
New York, N.Y. : Springer Science+Business Media, LLC, 2010.
Series:
Current cancer research
Current cancer research.
Format/Description:
Book
xiv, 494 p. ill.
Subjects:
Medicine.
Oncology.
Toxicology.
Medical subjects:
Neoplasms -- drug therapy.
Protein Kinase C -- therapeutic use.
Intercellular Signaling Peptides and Proteins.
System Details:
Mode of access: Internet.
Contents:
Protein kinase C in cancer signaling and therapy: introduction and historical perspective
Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids
Phorbol esters and diacylglycerol: the PKC activators
Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals
Regulation of PKC by protein-protein interaction in cancer
Introduction: PKC isozymes in the control of cell function
Regulation and function of protein kinase C signaling
PKC and control of the cell cycle
PKC and the control of apoptosis
Atypical PKC's, NF-kB and inflammation
Introduction: PKC and cancer
Protein kinase C, p53, and DNA damage
PKCs as mediators of the hedgehog and Wnt signaling pathways
PKC-PKD interplay in cancer
Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the developoment of squamous cell carcinoma, a nonmelanoma human skin cancer
PKC isozymes and skin cancer
PKC and breast cancer
PKC and prostate cancer
Protein kinase C and lung cancer
Introduction [PKC isozymes as targets for cancer therapy]
PKC and resistance to chemotherapeutic agents
PKCd as a target for chemotherapeutic drugs
Atypical PKCs as targets for cancer therapy.
Contributor:
Kazanietz, Marcelo G.
SpringerLink (Online service)
Contained In:
Springer eBooks
ISBN:
9781607615439
9781607615422
1607615428
1607615436
OCLC:
654388681
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