Franklin

Micromaterial characterizations of the red cell membrane and block copolymer mimetics [electronic resource].

Author/Creator:
Lee, James Chak-Man.
Format/Description:
Book
171 p.
Subjects:
Chemical engineering
Cytology
Local subjects:
0379
0542
Penn dissertations -- Chemical engineering.
Chemical engineering -- Penn dissertations.
System Details:
Mode of access: World Wide Web.
Summary:
Various aspects of both red cell and polymer membranes were investigated. For red cell membranes, the ability of the red cell's spectrin-actin network to sustain a very large and anisotropic strain was demonstrated in fluorescence-patterned network deformation. Tracking the constrained thermal motions of network-attached nano-particles revealed the softness of the network. The large but constrained thermal motions of the highly extended network suggested a role for the unfolding of spectrin in cell mechanics.
For polymer membranes, their robust preparation, stability, and in vitro biocompatibily were demonstrated. The hydration of both polymer and phospholipid membranes quantified by an amphiphilic probe's fluorescence was correlated to micropipette-measured thermomechanical properties. Finally, the fluidity of phospholipid and polymer membranes were measured by fluorescence recovery after photobleaching (FRAP) using confocal laser microscopy.
Notes:
Thesis (Ph.D. in Chemical Engineering) -- University of Pennsylvania, 2000.
Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 3166.
Local notes:
School code: 0175.
Contributor:
University of Pennsylvania.
Contained In:
Dissertation Abstracts International 61-06B.
ISBN:
9780599821606
Access Restriction:
Restricted for use by site license.
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