Franklin

Biologic foundations for skeletal tissue engineering [electronic resource] / Ericka M. Bueno, Julie Glowacki.

Author/Creator:
Bueno, Ericka M.
Publication:
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, c2011.
Format/Description:
Book
1 electronic text (viii, 210 p.) : ill., digital file
Series:
Synthesis digital library of engineering and computer science.
Synthesis lectures on tissue engineering 1944-0308 ; # 7.
Synthesis lectures on tissue engineering, 1944-0308 ; # 7
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Subjects:
Tissue engineering.
Bone regeneration.
Cartilage -- Regeneration.
Medical subjects:
Tissue Engineering.
Bone Regeneration.
Cartilage.
System Details:
Mode of access: World Wide Web.
Summary:
Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients.
Contents:
1. Introduction

2. Structure and function of bone and cartilage tissue
Bone
Structure
Function
Mechanical properties
Articular cartilage
Structure
Function
Mechanical properties

3. Development
Intramembranous bone formation
Endochondral bone formation
Articular cartilage

4. Responses to injury and grafting
Bone
Microfractures
Bone fractures
Fracture healing
Distraction osteogenesis
Comparison of post-natal fracture healing and skeletal embryogenesis
Bone grafts, implants, and bone substitute materials
Cartilage

5. Clinical applications for skeletal tissue engineering
Disorders in bone
Focal deficiencies
Systemic disorders of bone
Cartilage
Osteoarthritis
Rheumatoid arthritis
Osteochondritis dissecans
Temporomandibular joint (TMJ) disorders

6. Animal models
Bone
Biocompatibility
Osteocompatibility
Bone substitutes
Clinical relevance
Cartilage

7. Tissue engineering principles for bone and cartilage
Bone
Scaffolds
Bioactive factors
Cells
In vitro studies
In vivo studies
Cartilage
Scaffolds
Bioactive factors
Cells
In vitro studies
In vivo studies

8. Perspectives
References
Authors' biographies.
Notes:
Part of: Synthesis digital library of engineering and computer science.
Series from website.
Includes bibliographical references (p. 127-208).
Contributor:
Glowacki, Julie.
ISBN:
9781608451739 (electronic bk.)
9781608451722 (pbk.)
Publisher Number:
10.2200/S00329ED1V01Y201101TIS007 doi
Access Restriction:
Restricted for use by site license.