Translational stroke research : from target selection to clinical trials / Paul A. Lapchak, John H. Zhang, eds.

New York : Springer, 2012.
Springer series in translational stroke research
Springer series in translational stroke research
xxiv, 923 p. : ill. (some col.) ; 24 cm.
Cerebrovascular disease -- Research.
Medical subjects:
Stroke -- therapy.
Translational Medical Research.
pt. 1. Theoretical overview
Vascular targets for ischemic stroke treatment / Sara Morales Palomares and Marilyn J. Cipolla
Identifying vascular targets to treat hemorrhagic stroke / Paul A. Lapchak
Experimental platforms for assessing white matter pathophysiology in stroke / Ken Arai, Loc-Duyen D. Pham and Eng H. Lo
Neuroprotection in stroke / Aarti Sarwal, Muhammad Shazam Hussain and Ashfaq Shuaib.
pt. 2. Mechanisms & Targets
Protein aggregation and multiple organelle damage after brain ischemia / Chunli H. Liu, Fan Zhang, Tibor Krisrian, Brian Polster and Gary M. Fiskum, et al.
Antioxidants and stroke: success and pitfalls / Fernanda M. F. Roleira, Elisiário J. Tavares-da-Silva, Jorge Garrido and Fernanda Borges
Caspase-independent stroke targets / Ruoyang Shi, Jiequn Weng, Paul Szelemej and Jiming Kong
Hypoxia-inducible factor: a new hope to counteract stroke / Chunhua Chen and Changman Zhou
Thrombin in ischemic stroke targeting / Bo Chen
Toll-like receptor agonists as antecedent therapy for ischemic brain injury: advancing preclinical studies to the nonhuman primate / Frances Rena Bahjat, Keri B. Vartanian, G. Alexander West and Mary P. Stenzel-Poore
Angiogenesis and arteriogenesis as stroke targets / Jieli Chen and Michael Chopp
Hematopoietic growth factor family for stroke drug development / Ihsan Solaroglu and Murat Digicaylioglu
Soluble epoxide hydrolase as a stroke target / Jonathan W. Nelson and Nabil J. Alkayed
Membrane potential as stroke target / Jens P. Dreier, Maren Winkler, Dirk Wiesenthal, Michael Scheel and Clemens Reiffurth
Hypothermia to identify therapeutic targets for stroke treatment / Masaaki Hokari and Midori A. Yenari
Stroke preconditioning to identify endogenous protective or regenerative mechanisms / Liren Qian, Prativa Sherchan and Xuejun Sun
microRNAs in ischemic brain: the fine-tuning specialists and novel therapeutic targets / Ashutosh Dharap, Venkata P. Nakka and Raghu Vemuganti
Neuroglobin: a novel target for endogenous neuroprotection / Zhanyang Yu, Ning Liu and Xiaoying Wang
Characterization of novel neuroprotective lipid analogues for the treatment of stroke / Pamela Maher, Alain César Biraboneye and Jean-Louis Kraus
Na+/H+ exchangers as therapeutic targets for cerebral ischemia / Yejie Shi and Dandan Sun
Iron as a therapeutic target in intracerebral hemorrhage: preclinical testing of deferoxamine / Ya Hua, Richard F. Keep, Yuxiang Gu and Guohua Xi
Potential therapeutic targets for cerebral resuscitation after global ischemia / Yan Xu
The splenic response to ischemic stroke: neuroinflammation, immune cell migration, and experimental approaches to defining cellular mechanisms / Christopher C. Leonardo, Hilary Seifert and Keith R. Pennypacker.
pt. 3. Translational models
overcoming barriers to translation from experimental stroke models / Ludmila Belayev
Animal models of stroke for preclinical drug development: a comparative study of flavonols for cytoprotection / Carli L. Roulston, Sarah McCann, Robert M. Weston and Bevyn Jarrott
Clinical relevance in a translational rodent model of acute ischemic stroke: incorporating the biological variability of spontaneous recanalization / Kama Guluma
A clinically relevant rabbit embolic stroke model for acute ischemic stroke therapy development: mechanisms and targets / Paul A. Lapchak
Animal models of intracranial aneurysms / Elena I. Liang, Hiroshi Makino, Yoshiteru Tada, Kosuke Wada and Tomoki Hashimoto
Animal models of sah and their translation to clinical sah / Tommaso Zoerle and R. Loch Macdonald.
pt. 4. De-risking of Drug Candidates
ADME (absorption, distribution, metabolism, excretion): the real meaning-avoiding disaster and maintaining efficacy for preclinical candidates / Katya Tsaioun and Steven A. Kates
CeeTox analysis to de-risk drug development: the three antioxidants (NXY-059, Radicut, and STAZN) / Paul A. Lapchak. pt. 5. Therapy Delivery
Site-specific, sustained-release drug delivery for subarachnoid hemorrhage / R. Loch Macdonald
Therapeutic potential of intranasal delivery of drugs and cells for stroke and other neurological diseases / Heyu Chen, Caibin Sheng, Weiliang Xia and Weihai Ying.
pt. 6. Therapy Development
High-dose albumin for neuroprotection in acute ischemic stroke: from basic investigations to multicenter clinical trial / Myron D. Ginsberg
The translation procedure of low-level laser therapy in acute ischemic stroke: a nonpharmaceutics noninvasive method / Yair Lampl
Use of microbubbles in acute stroke / Marta Rubiera and Carlos A. Molina
Transcranial high-intensity focused ultrasound for sonothrombolysis in stroke / Thilo Hölscher, Golnaz Ahadi, Daniel Lotz, Cheryl Schendel and David Fisher, et al.
Cellular therapy for ischemic stroke / Todd Deveau, Shan Ping Yu and Ling Wei.
Includes bibliographical references and index.
Lapchak, Paul A.
Zhang, J. H. (John H.)
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