Franklin

Introduction to Evolutionary Genomics / Naruya Saitou.

Author/Creator:
Saitou, Naruya.
Publication:
London : Springer-Verlag, 2013.
Format/Description:
Book
xxiii, 461 p. : ill. ; 24 cm.
Series:
Computational biology; 17.
Computational biology
Status/Location:
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Details

Subjects:
Evolutionary genetics -- Statistical methods.
Genomics.
Gene mapping.
Evolution (Biology).
Summary:
Evolutionary genomics is a new discipline that bridges the fields of molecular evolution, bioinformatics and genomics in order to provide a unique perspective on the history of life. This easy-to-follow textbook is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Topics and features: Introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection Presents a brief evolutionary history of life from the primordial seas to the emergence of modern humans Describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans Reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building. Discusses databases of genome sequences and related information, evolutionary distances, and population genomics Provides supplementary material at the website http://www.saitou-naruya-laboratory.org/Evolutionary_Genomics/ This essential text/reference provides an easy-to-read introduction to the field for undergraduate and graduate students, post-doctoral fellows, and established researchers from both computer science and the biological sciences.
Contents:
Part I: Basic Processes of Genome Evolution
Basic Metabolism Surrounding DNAs
Mutation
Phylogeny
Neutral Evolution
Natural Selection
Part II: Evolving Genomes
Brief History of Life
Prokaryote Genomes
Eukaryote Genomes
Vertebrate Genomes
Human Genomes
Part III: Methods for Evolutionary Genomics
Genome Sequencing
Omic Data Collection
Databases
Sequence Homology Handling
Evolutionary Distances
Tree and Network Building
Population Genomics.
Notes:
Includes bibliographical references and index.
Local notes:
Acquired for the Penn Libraries with assistance from the Rudolph G. Schmieder Fund.
Contributor:
Rudolph G. Schmieder Fund.
ISBN:
1447153030
OCLC:
857973608
Publisher Number:
99958052270