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Chemical Biology of Nucleic Acids [electronic resource]. Fundamentals and Clinical Applications / edited by Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski.

Author/Creator:
Erdmann, Volker A. editor.
Publication:
Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
Format/Description:
Book
1 online resource : color illustration
Series:
RNA technologies
RNA Technologies
Contained In:
Springer eBooks
Status/Location:
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Details

Subjects:
Life sciences.
Human genetics.
Medicine.
Nucleic acids.
System Details:
Mode of access: World Wide Web.
text file PDF
Summary:
This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Contents:
RNA as Major Components in Chemical Evolvable Systems
How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems
Isomerization of RNA Phosphodiester Linkages
Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids
Oxidative Damage on RNA Nucleobases
Use of FRET to Study Dynamics of DNA Replication
Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds
Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies
Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids
Sequence Selective Recognition of Double-Stranded RNA
Determining Transient Nucleic Acid Structures by NMR
Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties
Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms
Progress in Chemically Modified Nucleic Acid Aptamers
Aptamers as Molecular Smugglers
Biochemical Aspects of Subcellular RNA Transport and Localization
Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology
Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression
Site Directed Spin Labelling of RNA for Distance Measurements by EPR
Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells
Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics
Peptides Targeting G-Quadruplex Structures
Synthesis of Site-Specifically Modified Long-Mer RNAs
Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs
mRNA and snRNA Cap Analogs: Synthesis and Applications
Innovative Chemistry for Synthesis of Regular RNA, 5’-Triphosphate RNA or 5’-Capped RNA.
Contributor:
Markiewicz, Wojciech T. editor.
Barciszewski, Jan. editor.
SpringerLink (Online service)
ISBN:
9783642544521
Publisher Number:
10.1007/978-3-642-54452-1 doi
Access Restriction:
Restricted for use by site license.