Vesicular transport in the secretory and endocytic pathways [electronic resource] / Anne Müsch.

Müsch, Anne., author.
San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.
Colloquium digital library of life sciences.
Colloquium series on building blocks of the cell ; 2328-305X # 8.
Colloquium series on building blocks of the cell, 2328-305X ; # 8
1 online resource (viii, 125 pages) : illustrations
Biological transport.
Proteins -- Physiological transport.
Medical subjects:
Biological Transport.
Protein Transport.
Bodily Secretions.
System Details:
Mode of access: World Wide Web.
The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments.
1. Compartmentalization is a hallmark of eukaryotic cells

2. Organelles can be classified based on their origin

3. There are multiple entry points into the endomembrane system and a network of connecting trafficking routes
3.1 The exocytic pathway
3.2 The endocytic pathway
3.3 The ER-peroxisome pathway

4. There are exceptions and extensions to the classic trafficking itineraries
4.1 Unconventional secretion
4.2 Vesicular transport from mitochondria to peroxisomes and lysosomes

5. A mathematical model can explain how organelle size is established and maintained

6. Coats and snares constitute the core machinery for vesicle budding and fusion
6.1 Vesicle formation
6.2 Vesicle fission
6.3 Vesicle fusion

7. A mathematical model explains how coats and snares are sufficient to generate organelle identity

8. How vesicle formation is linked to cargo incorporation
8.1 How to avoid empty vesicles
8.2 The nature of coat-cargo interactions
8.3 Clathrin coated vesicles, endocytosis and exit from the TGN
8.4 COPII vesicles, exit from the ER
8.5 COPI vesicles, ER retrieval and intra-Golgi transport
8.6 Sorting roles of transmembrane domains
8.7 Sugars as luminal sorting determinants

9. RabGTPases are the master regulators of vesicular traffic
9.1 Rab-mediated regulation of coat-cargo recruitment
9.2 Vesicle uncoating and tethering
9.3 Rab proteins and the actin and microtubule (MT) cytoskeleton in vesicular traffic
9.4 Rab proteins and phosphoinositide lipids
9.5 Rab domains and Rab cascades

10. The mechanisms and physiological roles of endocytosis

11. Models for protein transport in the Golgi apparatus

12. Summary
Author biography.
Part of: Colloquium digital library of life sciences.
Title from PDF title page (viewed on September 20, 2014).
Includes bibliographical references (pages 93-123).
Publisher Number:
10.4199/C0011ED1V01Y201407BBC008 doi
Access Restriction:
Restricted for use by site license.
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