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Organic Cation Transporters : Integration of Physiology, Pathology, and Pharmacology / edited by Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter.

Publication:
Cham : Springer International Publishing : Imprint: Springer, 2016.
Format/Description:
Book
1 online resource
Edition:
1st ed. 2016.
Contained In:
Springer eBooks
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Details

Subjects:
Medicine.
Human physiology.
Pharmacology.
Pathology.
System Details:
Mode of Access: World Wide Web.
text file PDF
Summary:
This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues.   This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
Contents:
Introduction to the cellular transport of organic cations
Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism
Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity
Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy
Physiological and pathological regulation of transporters for organic cations
Endocrine and metabolic regulation of transporters for organic cations
Organic cation transporters (OCTs) as modulators of behavior and mood
Organic cation transporters as modulators of neurodegeneration and neuroprotection
Translational relevance of animal models for the study of organic cation transporter function
Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.
Contributor:
Ciarimboli, Giuliano. editor.
Gautron, Sophie. editor.
Schlatter, Eberhard, editor.
SpringerLink (Online service)
Other format:
Printed edition:
ISBN:
978-3-319-23793-0
9783319237930
Publisher Number:
10.1007/978-3-319-23793-0 doi
Access Restriction:
Restricted for use by site license.