Biomarkers in Alzheimer's disease [electronic resource] / T.K. Khan.

Khan, T. K.
London, United Kingdom : Academic Press : Elsevier, 2016.
1 online resource.
Alzheimer's disease -- Molecular aspects.
Biochemical markers.
Cover ; Title page; Copyright page; Contents; Foreword; Preface; Acknowledgments; Chapter 1
Introduction to Alzheimer's Disease Biomarkers ; 1.1
Historical Background; 1.2
Important Events in Alzheimer's Disease (AD) Research; 1.3
Some Facts About Alzheimer's Disease; 1.4
Common Features of Alzheimer's Disease; 1.5
Classification of Alzheimer's Disease; 1.6
Risk Factors for Alzheimer's Disease; 1.7
Definition of a Biomarker; 1.7.1
A. Categorization of Biomarkers According to Their Role
B. Definition of Common Statistical Parameters to Quantify the Performance of Biomarkers1.8
Biomarkers of Alzheimer's Disease; 1.9
Future Focus: Detecting Preclinical Stages of Alzheimer's Disease; 1.10
Economic Impact of Alzheimer's Disease Biomarkers; 1.11
Conclusions; Bibliography; Chapter 2
Clinical Diagnosis of Alzheimer's Disease ; 2.1
Clinical Diagnosis of Alzheimer's Disease: Historical Perspective; 2.2
Neuropsychological Assessment Tests to Diagnose Alzheimer's Disease; 2.2.1
Mini-Mental State Examination; 2.2.2
Clock Drawing Test
Alzheimer's Disease Assessment Scale2.2.4
Neuropsychological Test Battery;
Other neuropsychological tests; 2.2.5
Clinical Dementia Rating; 2.2.6
Global Deterioration Scale; 2.2.7
Dementia Severity Rating Scale; 2.3
Neuropathology at Brain Autopsy to Diagnose Alzheimer's Disease; 2.4
Accuracy of Clinical Diagnosis of Alzheimer's Disease; 2.5
Alzheimer's Disease-Related Neurological Conditions; 2.5.1
Preclinical Alzheimer's Disease; 2.5.2
Mild Cognitive Impairment; 2.5.3
Non-Alzheimer's Dementias;
Vascular dementia;
Lewy body dementia
Frontotemporal dementia2.5.3.4
Creutzfeldt-Jacob disease;
Other non-AD dementias; 2.6
Challenges in Diagnosing Alzheimer's Disease; 2.6.1
Long Prodromal Stages; 2.6.2
Comorbidity With Non-Alzheimer's Disease Dementias; 2.6.3
Multiple Nongenetic and Genetic Factors; 2.6.4
Anomalous Alzheimer's Disease Neuropathology; 2.7
Comprehensive Alzheimer's Disease Diagnostic Framework; 2.8
Conclusions; Bibliography; Chapter 3
Neuroimaging Biomarkers in Alzheimer's Disease ; 3.1
Neuroimaging in Alzheimer's Disease; 3.1.1
Structural Neuroimaging
Functional Neuroimaging3.1.3
Molecular Neuroimaging; 3.2
Common Neuroimaging Alzheimer's Disease Biomarkers and Modalities; 3.3
Magnetic Resonance Imaging; 3.3.1
Structural MRI; 3.3.2
Functional MRI; 3.3.3
Magnetic Resonance Spectroscopy; 3.3.4
Advanced Magnetic Resonance Based Neuroimaging Modalities;
Diffusion tensor imaging;
Arterial spin labeling MRI;
Task free fMRI; 3.4
Positron Emission Tomography; 3.4.1
Amyloid Imaging by PET; 3.4.2
Glucose Metabolism Measurement by PET; 3.4.3
Brain Inflammation Imaging by PET
Tau Imaging by PET
Electronic reproduction. Amsterdam Available via World Wide Web.
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Includes index.
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Acquired for the Penn Libraries with assistance from the Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.
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