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DNA Methyltransferases - Role and Function [electronic resource] / edited by Albert Jeltsch, Renata Z. Jurkowska.

Publication:
Cham : Springer International Publishing : Imprint: Springer, 2016.
Series:
Advances in Experimental Medicine and Biology, 0065-2598 ; 945
Advances in Experimental Medicine and Biology, 0065-2598 ; 945
Format/Description:
Book
1 online resource
Subjects:
Life sciences.
Gene expression.
Cytogenetics.
Cell biology.
System Details:
text file PDF
Summary:
DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.
Contents:
Mechanisms and biological roles of DNA methylation and DNA methyltransferases – from past achievements to future challenges
DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position
Bacterial DNA methylation and methylomes
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases
Enzymology of mammalian DNA methyltransferases
Genetic studies on mammalian DNA methyltransferases
The role of DNA methylation in cancer
Structure and mechanism of plant DNA methyltransferases
DNA methylation and gene regulation in honey bees: from genome-wide analyses to obligatory epi-alleles
N6-methyladenine: a conserved and dynamic DNA mark
Pathways of DNA demethylation
Structure and function of TET enzymes
Proteins that read DNA methylation
DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications
Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns
DNA methyltransferase inhibitors – development and applications
Rewriting DNA methylation signatures at will: the curable genome within reach?
Engineering and directed evolution of DNA methyltransferases
DNA labeling using DNA methyltransferases.
Contributor:
Jeltsch, Albert. editor.
Jurkowska, Renata Z. editor.
SpringerLink (Online service)
Contained In:
Springer eBooks
Other format:
Printed edition:
ISBN:
9783319436241
Publisher Number:
10.1007/978-3-319-43624-1 doi
Access Restriction:
Restricted for use by site license.
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