Franklin

Muscle aging [electronic resource] : inclusion-body myositis and myopathies / edited by Valerie Askanas and w. King Engel.

Publication:
Oxford : Wiley-Blackwell, 2012.
Format/Description:
Book
1 online resource (272 p.)
Subjects:
Inclusion body myositis.
Form/Genre:
Electronic books.
Language:
English
Summary:
The aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management
Contents:
Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas
Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas
Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas
Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano
Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies
Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen
Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska
Inflammatory and autoimmune features of inclusion-body myositis / Marinos Dalakas
Clinical symptoms, physical findings, and diagnostic investigations / Frank Mastaglia
Pathologic diagnostic criteria of s-IBM and h-IBMS muscle biopsies / Valerie Askanas and W. King Engel
Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments / May Malicdan, Satoru Noguchi, Ichizo Nishino
Clinical and ethnic spectrum, laboratory data, and epidemiology of h-IBM due to GNE mutations / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka
Consequences of the h-IBM characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella
Function and structure of VCP mutations leading to h-IBM / Cezary Wojcik
Clinical spectrum, including myopathy, Paget's disease, and fronto-temporal dementia : experimental models of VCP mutations, and potential treatments / Virginia Kimonis
Animal models of h-IBM due to VCP mutation / Nisha M. Badders and Paul Taylor.
Notes:
Description based upon print version of record.
Includes bibliographical references and index.
Contributor:
Askanas, Valerie.
Engel, W. King.
ISBN:
1-4443-9829-6
1-4443-9831-8
1-283-40875-9
9786613408754
1-4443-9828-8
OCLC:
773301453
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