Franklin

Purine and pyrimidine metabolism [electronic resource].

Author/Creator:
Symposium on Purine and Pyrimidine Metabolism Corporate Author
Publication:
Amsterdam ; New York : Elsevier/Excerpta Medica/North-Holland, 1977.
Conference Name:
Symposium on Purine and Pyrimidine Metabolism (1976 : London, England)
Symposium on Purine and Pyrimidine Metabolism
Series:
Ciba Foundation symposium ; new ser. 48.
Ciba Foundation symposium (new series) ; 48
Format/Description:
Conference/Event
Book
1 online resource (384 p.)
Subjects:
Purines -- Metabolism -- Congresses.
Pyrimidines -- Metabolism -- Congresses.
Form/Genre:
Electronic books.
Language:
English
Contents:
Purine and Pyrimidine Metabolism; Contents; Chairman's opening remarks; Purine and pyrimidine metabolism : pathways, pitfalls and perturbations; Discussion; Microbial models and regulatory elements in the control of purine metabolism; Discussion; Molecular nature of enzyme regulation in purine biosynthesis; Discussion; Genetic heterogeneity at the locus for hypoxanthine-guanine phosphoribosyltransferase; Discussion; Factors in the pathogenesis of the brain damage and anaemia in the Lesch-Nyhan syndrome; Discussion
Hypoxanthine-guanine phosphoribosyltransferase activity in individual erythrocytes: autoradiographic studies in heterozygotDiscussion; Purine biosynthesis in mutant mammalian cells; Discussion; Purine and pyrimidine nucleotides in some mutant human lymphoblasts; Discussion; Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout; Discussion; Dietary feedback regulation of purine and pyrimidine biosynthesis in man; Discussion; Implications of disorders of purine metabolism for the kidney and the urinary tract; Discussion
The role of de novo purine synthesis in lymphocyte transformationDiscussion; Purine metabolism and control of cell proliferation; Discussion; The effect of adenosine on lymphoid cell proliferation and antibody formation; Discussion; Characterization of human adenosine deaminase; Discussion; The purinergic nerve hypothesis; Discussion; Inherited metabolic disease: prospects for the future in both basic and clinical research; Discussion; General discussion; Purine as regulators; Extracellular effects of adenosine; Membrane transport; Pyrimidine metabolism and immune function
Allopurinol and purine transportModel systems for the study of purine and pyrimidine metabolism and their limitations; Animal models; Assessment of treatment : the Lesch-Nyhan syndrome; Ribose 5-phosphate and the oxidative pentose shunt in the regulation of purine synthesis de novo; Index of contributors; Subject index
Notes:
"Symposium on Purine and Pyrimidine Metabolism held at the Ciba Foundation, London, 9-11th June, 1976"--Participants page.
Includes bibliographical references and indexes.
ISBN:
1-280-78367-2
9786613694065
0-470-72030-1
0-470-71798-X
OCLC:
798207670
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