Franklin

Mathematical modeling in systems biology [electronic resource] : an introduction / Brian P. Ingalls.

Author/Creator:
Ingalls, Brian P., 1974-
Publication:
Cambridge, Mass. : MIT Press, 2013.
Format/Description:
Datafile
1 online resource (423 p.)
Subjects:
Biological control systems.
Control theory.
Form/Genre:
Electronic books.
Language:
English
Summary:
An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology.
Contents:
Contents; Preface; 1 Introduction; 1.1 Systems Biology and Synthetic Biology; 1.2 What Is a Dynamic Mathematical Model?; 1.3 Why Are Dynamic Mathematical Models Needed?; 1.4 How Are Dynamic Mathematical Models Used?; 1.5 Basic Features of Dynamic Mathematical Models; 1.6 Dynamic Mathematical Models in Molecular Cell Biology; 1.7 Suggestions for Further Reading; 2 Modeling of Chemical Reaction Networks; 2.1 Chemical Reaction Networks; 2.2 Separation of Timescales and Model Reduction; 2.3 Suggestions for Further Reading; 2.4 Problem Set; 3 Biochemical Kinetics; 3.1 Enzyme Kinetics
3.2 Regulation of Enzyme Activity3.3 Cooperativity; 3.4 Compartmental Modeling and Transport; 3.5* Generalized Mass Action and S-System Modeling; 3.6 Suggestions for Further Reading; 3.7 Problem Set; 4 Analysis of Dynamic Mathematical Models; 4.1 Phase Plane Analysis; 4.2 Stability; 4.3 Limit-Cycle Oscillations; 4.4 Bifurcation Analysis; 4.5 Sensitivity Analysis; 4.6* Parameter Fitting; 4.7 Suggestions for Further Reading; 4.8 Problem Set; 5 Metabolic Networks; 5.1 Modeling of Metabolism; 5.2 Metabolic Pathways; 5.3 Modeling of Metabolic Networks; 5.4* Stoichiometric Network Analysis
5.5 Suggestions for Further Reading5.6 Problem Set; 6 Signal Transduction Pathways; 6.1 Signal Amplification; 6.2 Ultrasensitivity; 6.3 Adaptation; 6.4 Memory and Irreversible Decision-Making; 6.5 Frequency Encoding; 6.6* Frequency Response Analysis; 6.7 Suggestions for Further Reading; 6.8 Problem Set; 7 Gene Regulatory Networks; 7.1 Modeling of Gene Expression; 7.2 Genetic Switches; 7.3 Oscillatory Gene Networks; 7.4 Cell-to-Cell Communication; 7.5 Computation by Gene Regulatory Networks; 7.6* Stochastic Modeling of Biochemical and Genetic Networks; 7.7 Suggestions for Further Reading
7.8 Problem Set8 Electrophysiology; 8.1 Membrane Potential; 8.2 Excitable Membranes; 8.3 Intercellular Communication; 8.4* Spatial Modeling; 8.5 Suggestions for Further Reading; 8.6 Problem Set; Appendix A: Molecular Cell Biology; Appendix B: Mathematical Fundamentals; Appendix C: Computational Software; Bibliography; Index
Notes:
Description based upon print version of record.
Includes bibliographical references and index.
ISBN:
0-262-31563-7
OCLC:
853455800
Loading...
Location Notes Your Loan Policy
Description Status Barcode Your Loan Policy