International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.* Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists
Front Cover; International Review of Cell and Molecular Biology; Copyright Page; Contents; Contributors; Chapter 1: Roles of Caldesmon in Cell Motility and Actin Cytoskeleton Remodeling; Introduction; Organization and Regulation of Caldesmon (CALD1) Gene; Caldesmon gene organization; Regulation of CALD1 gene expression; Regulation of 5'-splice site selection in exon 3 of human CALD1 gene; Transcriptional regulation of chicken Cald1 gene; Structure and Function Study of CaD; Domains for the bindings to CaD-interacting proteins; Phosphorylated residues on CaD by various kinases CaD and calponin interactionCaD and Regulation of Smooth Muscle Contraction; CaD and Regulation of Nonmuscle Cell Motility and Cytoskeleton Dynamics; Intracellular localization of l-CaD and its functions; Regulation of l-CaD activity in nonmuscle cells; CaD-mediated stabilization of actin microfilament bundles; Regulation of CaD activity by Ca2+ndash; calmodulin innonmusclecells; Regulation of CaD activity by phosphorylation innonmusclecells; Phosphorylation of l-CaD by Cdc2 kinase; Phosphorylation of l-CaD by ERK; Phosphorylation of l-CaD by PAK; CaD, Podosomes, and Diseases Concluding RemarksAcknowledgments; References; Chapter 2: Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle: Gonadotropin-Releasing Hormone, Glutamate, and GABA; 1. Introduction; 2. The HPG Axis; 3. The Reproductive Life Cycle in Females; 4. Glutamate and the HPG Axis; 5. Gamma-Aminobutyric Acid (GABA) and the HPG Axis; 6. Glutamate/GABA Interactions; 7. Conclusion; Chapter 3: Acquisition of Membrane Polarity in Epithelial Tube Formation: Patterns, Signaling Pathways, Molecular Mechanisms, and Disease; 1. Introduction 2. Architecture of Polarized Cells in Epithelial Organs3. Epithelial Morphogenesis into Tubes; 4. De Novo Formation of Tubes: Conserved Pathways and Molecular Mechanisms; 5. Epithelial Polarity and Disease; 6. Concluding Remarks; Acknowledgments; References; Chapter 4: Functions of RAB and SNARE Proteins in Plant Life; 1. Introduction; 2. General Features of Membrane Trafficking and Functions of RABs and SNAREs; 3. Molecular/Cellular Research on Plant RABs and SNAREs; 4. RABs and SNAREs in Higher Order Plant Functions; 5. A Unique Regulatory System in Plants for Endocytic/Vacuolar Transport 6. Concluding Remarks and Future IssuesAcknowledgments; Chapter 5: Rab Proteins and Their Interaction Partners; 1. Introduction; 2. Rab Proteins; 2.1. Rab family; 2.2. GTPase cycle of Rab proteins; 2.3. Structure and phylogeny of Rab GTPases; 2.4. Rab GTPases and malignancies; 3. Small GTPases Rab1, Rab6, and Their Effectors; 4. Concluding Remarks; Chapter 6: Chapter Six Cubic Membranes: The Missing Dimension of Cell Membrane Organization; 1. Introduction; 2. Cell Membrane Architecture; 2.1. Membrane symmetries; 2.2. Membrane polymorphisms; 2.3. Cubic membranes versus cubic phases 2.4. Understanding membrane morphology by transmission electron microscopy
Description based upon print version of record. Includes bibliographical references and index.