Mechanosensitive ion channels. Pt. B [electronic resource] / edited by Owen P. Hamill.

Amsterdam : Academic Press, 2007.
1 online resource (610 p.)
Current topics in membranes ; v. 59.
Current topics in membranes, 1063-5823 ; v. 59
Mechanosensitive ion channels

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Ion channels.
Membrane proteins.
Biological transport, Active.
Electronic books.
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potent
Front Cover; Mechanosensitive Ion Channels, Part B; Copyright Page; Contents; Contributors; Foreword; Previous Volumes in Series; Chapter 1: Mechanosensitive Ion Channels of Spiders: Mechanical Coupling, Electrophysiology, and Synaptic Modulation; I. Overview; II. Introduction; III. Types of Spider Mechanoreceptors; IV. Mechanical Coupling; V. Mechanotransduction in Slit Sensilla; A. The Ionic Selectivity of Spider Mechanosensitive Channels; B. The Location of VS-3 Mechanosensitive Channels; C. Mechanosensitive Channel Conductance, Density, and pH Sensitivity
D. Temperature Sensitivity of Mechanosensitive ChannelsE. Molecular Characterization of Spider Mechanosensitive Channels; VI. Dynamic Properties of Mechanotransduction and Action Potential Encoding; VII. Calcium Signaling During Transduction by Spider Mechanoreceptors; VIII. Synaptic Modulation of Spider Mechanoreceptors; IX. Conclusions; Acknowledgments; References; Chapter 2: Ion Channels for Mechanotransduction in the Crayfish Stretch Receptor; I. Overview; II. Introduction; III. Morphology of the SRO; IV. Functional Properties; A. General Behavior
B. Viscoelastic Properties of the Receptor MusclesC. MSCs in the Receptor Neurons; D. Macroscopic Receptor Currents in the Stretch Receptor Neurons; E. Pharmacology of the Crayfish MSCs; F. Voltage-Gated Ion Channels and the Generation of Impulse Response; G. Adaptation: A Multifactor Property; V. Summary and Discussion of Future Research Directions; Acknowledgments; References; Chapter 3: Mechanosensitive Ion Channels in Caenorhabditis elegans; I. Overview; II. Introduction; III. C. elegans Mechanosensitive Behaviors; IV. C. elegans DEG/ENaCs; A. MEC-4 and MEC-10; B. UNC-8 and DEL-1
C. UNC-105V. C. elegans TRP Ion Channels; A. OSM-9 and OCR-2; B. TRP-4; VI. Concluding Remarks; References; Chapter 4: Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom; I. Overview; II. Introduction; III. Properties and Specificity of GsMTx4; A. Biochemical and Structural; B. Biophysical and Mechanistic; C. Specificity; IV. Cellular Sites for GsMTx4; A. TRPC1 Channel; B. TRPC6 Channel; V. Potential Therapeutic Uses for GsMTx4; A. Cardiac Myocytes and Atrial Fibrillation; B. Muscular Dystrophy
C. Astrocytes and GliosisD. Neurite Growth Extension; VI. Conclusions; References; Chapter 5: Mechanosensitive Channels in Neurite Outgrowth; I. Overview; II. Introduction; III. Encoding of Guidance Cues in Axon Pathfinding; IV. Requirement of TRP Channels in Calcium-Dependent Axon Pathfinding; V. Physical Guidance Cues and Role of Mechanosensitive Ion Channels; VI. Ion Channels as Molecular Integrators; VII. Concluding Remarks; Note Added in Proof; Acknowledgments; References; Chapter 6: ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; I. Overview; II. Introduction
III. DEG/ENaC/ASIC Proteins are Members of a Diverse Protein Family Involved in Mechanotransduction
Description based upon print version of record.
Includes bibliographical references and index.
Hamill, Owen P.