Franklin

Neurotrauma [electronic resource] : new insights into pathology and treatment / edited by John T. Weber, Andrew I.R. Maas.

Publication:
Amsterdam ; Oxford : Elsevier, 2007.
Format/Description:
Book
1 online resource (461 p.)
Series:
Progress in brain research ; v. 161.
Progress in brain research ; v. 161
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Subjects:
Nervous system -- Wounds and injuries.
Brain -- Wounds and injuries.
Spinal cord -- Wounds and injuries.
Form/Genre:
Electronic books.
Language:
English
Summary:
Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in
Contents:
Cover; Contents; List of Contributors; Preface; Section I: Introduction; Chapter 1. The impact of neurotrauma on society: an international perspective; Introduction; Neurotrauma as a global problem; The causes of neurotrauma; The community costs; Providing care; What can be done?; Community support for research; The challenge; The role of the INTS and neuroscience; References; Section II: Biomechanics of Injury; Chapter 2. CNS injury biomechanics and experimental models; Introduction; Basic biomechanics; Traumatic mechanical insults; Mechanical response to traumatic insult
Astrocytes in normal brain function: recasting an old ''star''Revisiting and revising the ''Classical View'' of astrocytes in CNS trauma; Unraveling the mechanisms of acute astrocyte damage with in vitro mechanical injury; Conclusion; Acknowledgments; References; Chapter 6. Rescuing neurons and glia: is inhibition of apoptosis useful?; Introduction; Cell death routes; Apoptotic pathways; Crossroads of cell death; Inhibition of apoptosis; Concluding remarks; Abbreviations; Acknowledgments; References; Chapter 7. Substance P in traumatic brain injury; Introduction; Substance P
Neurogenic inflammationNK1 receptor antagonists; Conclusion; References; Chapter 8. Current concepts of cerebral oxygen transport and energy metabolism after severe traumatic brain injury; Cerebral oxygen transport; Cerebral energy metabolism; Pathophysiology; Abbreviations; References; Chapter 9. Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies; Introduction; Traumatic brain injury; Clinical evidence for progressive injury; Pathomechanisms underlying progressive injury; Spinal cord injury; Supraspinal alterations after SCI
Therapeutic interventions targeting progressive injury
Notes:
Description based upon print version of record.
Includes bibliographical references and index.
Contributor:
Weber, John T.
Maas, Andrew I. R.
ISBN:
1-281-11989-X
9786611119898
0-08-054887-3
OCLC:
469630024