Advances in protein chemistry and structural biology. Volume 80 [electronic resource] / edited by Rossen Donev.

1st ed.
Amsterdam ; Boston : Elsevier, c2010.
1 online resource (301 p.)
Electronic books.
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.While most structural biologists pursue structures of individual proteins or protein groups, spec
Front Cover; Advances in Protein Chemistry and Structural Biology; Copyright; Contents; Chapter 1: Proteomics technologies for the global identification and quantification of proteins; I. Proteomics in Context; II. Protein Identification Using Tandem Mass Spectrometry; III. Protein Quantification is a Major Goal of Proteomics; IV. Options for Improved Analyses and Challenges to Achieving Proteomic Coverage; V. Concluding Comments; Acknowledgments; References; Chapter 2: Targeted metabolomics and mass spectrometry; I. Introduction; II. Nucleic Acid Metabolism
III. Lipid Analysis by Mass SpectrometryIV. Bioactive Metabolite Screening in Herbal Remedies; V. Volatile Organic Compound Metabolites; VI. Peptidomics; VII. Conclusion; References; Chapter 3: Mechanisms of protein circular dichroism: insights from computational modeling; I. Introduction; II. Theoretical Background; III. Insights from Model Systems; IV. Tyrosine Interactions and Contributions in RNase A and RNase S; V. Toward Improved Accuracy Using Ab Initio Parameter Sets; VI. Far-UV Contributions of Tryptophans; VII. Mechanisms of CD Spectra in Class A beta-Lactamase; VIII. Conclusion
ReferencesChapter 4: Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling; I. Introduction; II. The Pentameric Ligand-Gated Ion Channel (LGIC) Family; III. The Inhibitory System Ion Channels; IV. Inhibitory System Receptor Structure; V. Molecular Modeling of Inhibitory System Receptors; VI. Mutations of the Inhibitory LGICs; VII. Where Can We Go from Here?; References; Chapter 5: Positive and negative modulation of nicotinic receptors; I. Introduction; II. Overall Structure of AChRs; III. The Gating Process
IV. Allosteric ModulatorsV. Summary; Acknowledgments; References; Chapter 6: Sonochemically born proteinaceous micro- and nanocapsules; I. Introduction; II. Methods for Protein Particle Preparation; III. Ultrasound Sonochemistry and Proteins; IV. Proteinaceous Microspheres Obtained Through Sonochemistry; V. Applications of the Proteinaceous Microcapsules; VI. Conclusions; Acknowledgment; References; Author Index; Subject Index; Color Plates
Description based upon print version of record.
Includes bibliographical references and index.
Donev, Rossen.
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