Franklin

Genetic dissection of neural circuits and behavior [electronic resource] / edited by Stephen F. Goodwin.

Publication:
Amsterdam ; Boston : Academic Press, c2009.
Format/Description:
Book
1 online resource (218 p.)
Edition:
1st ed.
Series:
Advances in genetics ; v. 65.
Advances in genetics, 0065-2660 ; 65
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Subjects:
Neural circuitry -- Adaptation.
Human genetics.
Form/Genre:
Electronic books.
Language:
English
Summary:
Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.* Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models* Includes methods for testing with ethical, legal, and social implications* Critically analyzes future prospects
Contents:
Front Cover; Genetic Dissection of Neural Circuits and Behavior; Copyright Page; Contents; Contributors; Chapter 1: Genetic Dissection of Neural Circuits and Behavior in Mus musculus; Abstract; I. Conventional Gene Targeting Strategies; II. Spatially Restricted Gene Manipulation; A. The Cre/loxP system; B. Investigating NMDA receptor function in specific subregions of the brain using the Cre/loxP system; III. The Use of Dominant Negative Inhibitors to Manipulate Gene Function; IV. Conditional Manipulation of Gene Function; A. The tTA system; B. A novel form of the tTA system: The rtTA system
V. Pharmacogenetic ApproachesA. Tamoxifen-controlled gene manipulation; B. Pharmacogenetic regulation of neuronal excitability; C. Targeting of intracellular signaling pathways using pharmacogenetic approaches; VI. Optogenetic Approaches; VII. Visualization of Brain Structure and Function; A. The TetTag system; B. The Brainbow mouse; VIII. The Challenges Facing Genetic Approaches in the Mouse; Acknowledgments; References; Chapter 2: Worm Watching: Imaging Nervous System Structure and Function in Caenorhabditis elegans; I. Introduction; II. Real-Time Indicators of Neuronal Activity
A. Properties of worm neuronsB. Speed of electrical signaling; III. Monitoring Intracellular Calcium; A. GECIs: Cameleon and G-CaMP; B. Examples of GECIs in worm neurobiology; C. Limitations of GECIs; IV. Imaging Presynaptic Terminals; Chapter 3: Mapping and Manipulating Neural Circuits in the Fly Brain; Chapter 4: A Network of G-Protein Signaling Pathways Control Neuronal Activity in C. elegans; Index; Color Plates
Notes:
Description based upon print version of record.
Includes bibliographical references and index.
Contributor:
Goodwin, Stephen F.
ISBN:
1-282-28942-X
9786612289422
0-08-095115-5
OCLC:
430341012