Advances in immunology. Volume one hundred and twenty three, Cell biology of the B cell receptor / edited by Hidde L. Ploegh ; series editor, Frederick W. Alt ; Ana M. Avalos [and eight others], contributors.

San Diego, California : Academic Press, 2014.
1 online resource (175 p.)
Advances in immunology ; Volume 123.
Advances in Immunology, 0065-2776 ; Volume 123

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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest devel
Front Cover; Cell Biology of the B Cell Receptor; Copyright; Contents; Contributors; Preface; Chapter One: B-Cell Receptor Signaling in Lymphoid Malignancies and Autoimmunity; 1. Introduction: B-Cell Behavior in Autoimmunity and B-Cell Malignancies; 2. Systemic Lupus Erythematosus; 3. B-Cell Malignancies; 4. Role of BCR in B-Cell Development and Selection; 4.1. Stages of B-cell development; 4.2. Central tolerance mechanisms; 4.3. B-cell selection in the periphery and activation; 5. BCR Activation by Antigen; 5.1. Early BCR events upon antigen binding
5.2. BCR signaling pathways in response to antigen5.3. Regulation of BCR signaling; 6. Breakdown of Tolerance by BCR Signaling Components; 6.1. Positive regulators: CD19 and tyrosine kinases; 6.2. Negative regulators: CD22 and FcγRIIB; 7. Aberrant Signaling Events Downstream of the BCR and Neoplasia; 8. Tonic BCR Signaling; 9. Antigen-Driven Malignant B-Cell Persistence; 10. The Role of Toll-Like Receptors in Breakdown of B-Cell Tolerance in Autoimmunity; 11. Contributions of TLR Signaling to Altered BCR Activity in Malignant B Cells
12. Similarities and Differences Between the Study of Aberrant B-Cell Receptor Signaling in Autoimmunity and in B-Cell Ma...13. Transnuclear Mice: Filling the Gaps Left by B-Cell Transgenesis; 13.1. Advantages of somatic cell nuclear transfer (SCNT); 13.2. Using transnuclear mice to study antigen valency and outcomes of B-cell activation; 14. Concluding Remarks; Acknowledgments; References; Chapter Two: A Critical Role for Cell Polarity in Antigen Extraction, Processing, and Presentation by B Lymphocytes; 1. Introduction; 2. B-Cell Activation in Secondary Lymphoid Organs
2.1. Antigen encounter by B cells2.2. The establishment of the immune synapse; 3. B-Cell Polarity and Antigen Processing and Presentation; 3.1. B-cell polarization upon particulate antigen stimulation; 3.2. Antigen extraction from antigen-presenting cell membranes; 3.3. Processing of antigen-BCR complexes; 3.4. Antigen presentation to helper T cells; 4. Extracellular Cues that Tune B-Cell Polarity and Activation; 4.1. Chemokines involved in follicle patrolling by B cells; 4.2. Galectins and B-cell function; 5. Concluding Remarks; Acknowledgments; References
Chapter Three: Force Generation in B-Cell Synapses: Mechanisms Coupling B-Cell Receptor Binding to Antigen Internalizatio...1. Introduction: Why Do B Cells Make Immune Synapses?; 2. Biomechanical Modules in B-Cell Synapses; 2.1. Spreading; 2.2. Clustering; 2.3. Pulling; 2.4. Transport; 2.5. Internalization; 3. Antigen Binding in B-Cell Synapses; 4. Affinity Discrimination in B-Cell Synapses; 4.1. Forces in affinity discrimination; 4.2. Implications for affinity maturation; 5. Conclusions and Perspective; Acknowledgment; References
Chapter Four: The Role of BCR Isotype in B-Cell Development and Activation
Description based upon print version of record.
Includes bibliographical references at the end of each chapters and index.
Description based on online resource; title from PDF title page (ebrary, viewed June 5, 2014).
Ploegh, Hidde L., editor.
Alt, Frederick W., editor.
Avalos, Ana M., contributor.