Franklin

Regenerative Medicine: Laboratory to Clinic / edited by Asok Mukhopadhyay.

Publication:
Singapore : Springer Singapore : Imprint: Springer, 2017.
Format/Description:
Book
1 online resource
Subjects:
Life sciences.
Human physiology.
Diagnosis, Laboratory.
Biomedical engineering.
Stem cells.
Regenerative medicine.
Tissue engineering.
Local subjects:
Life Sciences. (search)
System Details:
text file PDF
Summary:
This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering. It examines in detail the therapeutic application of hematopoietic stem cells in marrow regeneration, multi-potent mesenchymal stem cells (MSCs), also referred to as mesenchymal stromal cells. The interest in MSCs can be seen in more than 150 clinical trials, some of which have progressed to Phase III, despite the cells' limited differentiation potential. The book also explores how embryonic stem (ES) cells, being pluripotent in nature, can resolve some of the problems associated with adult stem cells, yet entail other challenges like risks of teratoma formation and immune rejection. A separate chapter deals with the role of noncoding RNAs in neuronal commitment of induced pluripotent stem (iPS) cells. Chapters like "Cord blood banking in India and the global scenario"; "3D bioprinting of tissue" and others will make this book an extremely interesting read for all students, researchers and clinicians working in the area of regenerative medicine/stem cells. The book is broadly divided into three parts, the first of which is devoted to basic information on stem cells and some aspect of disease biology, the second which addresses upcoming prospects in the regeneration of pancreas, liver, Lacrimal gland, and tissue engineering in general. Also, the second part discusses two important areas of translational regenerative medicine: challenges in pre-clinical study and manufacturing of cell based products. The third part covers bed side applications in the areas of orthopedic, eyes, hematology, dental tissue engineering, organ transplantation, control of aging, et cetera .
Contents:
Physical forces that regulate stem cell fate
Pluripotent stem cells: its potential applications
Unraveling the role of long-non coding RNAs in pluripotent stem cells-based neuronal commitment and neurogenesis
Control of quiescence in adult stem cells
Etiology and treatment of osteoarthritis: A developmental biological perspective
Differences in cell populations and expression of soluble mediators between normal wound healing and healing in the diabetic
MSC-derived exosomes as tools in regenerative medicine
Mixing of different batches of cells permits better therapeutic potential of MSCs
Blood to blood: new candidate for regenerative medicine
HSC based gene therapy for blood diseases
Allogeneic stem cell transplantation including haplo-identical stem cell transplants
Mesenchymal stem cells and transplantation tolerance
Ideal stem cell candidate for regenerative medicine
Pre-clinical/clinical study on idiopathic pulmonary fibrosis
Comparative analysis between ES and iPS cells for use in regenerative medicine: scope, advantage and safety
Regeneration of lacrimal gland: potential and progress
Clinical trials in cardiac regeneration using adult stem cells: Current and future prospects
Tissue engineering for the treatment of in large bone defect
Corneal Regeneration: Current status and future directions
Cell therapy for retinal regeneration: current progress and future challenges
Vaculogenesis: Importance in regeneration of solid organs
Cord blood banking in India and the global scenario
Prospects and retrospect of clinical applications of stem cell in veterinary sciences
Engineering of scaffolds for soft tissue engineering
3D bioprinting of tissue
Tissue engineering: Cell, scaffold and growth factor based strategies
Pre-clinical trial: A bottleneck that impedes development of regenerative medicine
Stem cell research work ethics and Indian stem cell research policy.
Contributor:
Mukhopadhyay, Asok. editor.
SpringerLink (Online service)
Contained In:
Springer eBooks
Other format:
Printed edition:
ISBN:
9789811037016
Publisher Number:
10.1007/978-981-10-3701-6 doi
Access Restriction:
Restricted for use by site license.
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