Chemical and biochemical approaches for the study of anesthetic function / edited by Roderic G. Eckenhoff, Ivan J. Dmochowski.

Cambridge, MA : Academic Press, an imprint of Elsevier, 2018.
Methods in enzymology ; 0076-6879 v. 602-603.
Methods in enzymology, 0076-6879 ; v. 602-603
2 volumes : illustrations (some color) ; 24 cm.
Anesthetics -- Mechanism of action.
Anesthetics -- Physiological effect.
Medical subjects:
Anesthetics -- pharmacokinetics.
Anesthesia, General.
Part A: "Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data. We have selected the primary experts to write about each approachThis provides one-stop shopping for all the means of addressing this complex questionAnesthesia is enormously important as almost everybody receives it at some point"-- Provided by publisher.
Part B: "Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more." -- Provided by publisher.
Part A: Chapter One: Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting with General Anesthetics / Sruthi Murlidaran, Grace Brannigan
Chapter Two: Computational Approaches to Studying Voltage-Gated Ion Channel Modulation by General Anesthetics / Eleonora Gianti, Vincenzo Carnevale
Chapter Three: Molecular Mechanics Parameterization of Anesthetic Molecules / Thomas T. Joseph, Jérôme Hénin
Chapter Four: Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic-Protein Interactions / Victoria S. Fahrenbach, Edward J. Bertaccini
Chapter Five: Understanding Anesthetic Mechanisms: Analysis of the Complex Kinetics of Ligand-Gated Ion Channels / Robert S. Cantor
Chapter Six: General Genetic Strategies / Louise M. Steele, Philip G. Morgan
Chapter Seven: Approaches to Anesthetic Mechanisms: The C. elegans Model / Louise M. Steele, Margaret M. Sedensky
Chapter Eight: Using Drosophila to Understand General Anesthesia: From Synapses to Behavior / Shanker Karunanithi, Michael Troup, Bruno van Swinderen
Chapter Nine: High-Throughput Screening to Identify Anesthetic Ligands Using Xenopus laevis Tadpoles / Kellie A. Woll, Roderic G. Eckenhoff
Chapter Ten: Zebrafish: A Pharmacogenetic Model for Anesthesia / Victoria Bedell, Elena Buglo, Daniel Marcato, Christian Pylatiuk, Ralf Mikut, Johannes Stegmaier, Will Scudder, Maxwell Wray, Stephan Zuchner, Uwe Strahle, Ravindra Peravali, and Julia E. Dallman
Chapter Eleven: The Mouse as a Model Organism for Assessing Anesthetic Sensitivity / Andrzej Z. Wasilczuk, Kaitlyn L. Maier, Max B. Kelz
Chapter Twelve: Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry / Kellie A. Woll, William P. Dailey, Roderic G. Eckenhoff
Chapter Thirteen: Xenon-Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR / Benjamin W. Roose, Serge D. Zemerov, Ivan J. Dmochowski
Chapter Fourteen: Methods for Defining the Neuroprotective Properties of Xenon / Richie Robel, Peter Caroccio, Mervyn Maze
Chapter Fifteen: Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration / Andrew McKinstry-Wu, Charles W. Carspecken, Alex Proekt, Max B. Kelz
Chapter Sixteen: Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms / Paul Hoerbelt, Boris D. Heifets
Chapter Seventeen: Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics / Elaine Yang, Lianteng Zhi, Qiansheng Liang, Manuel Covarrubias
Chapter Eighteen: Combining Mutations and Electrophysiology to Map Anesthetic Sites on Ligand-Gated Ion Channels / Stuart A. Forman
Chapter Nineteen: HCN and K2P Channels in Anesthetic Mechanisms Research / Paul M. Riegelhaupt, Gareth R. Tibbs, Peter A. Goldstein.
Part B: Chapter One: Structural Analysis of Anesthetics in Complex with Soluble Proteins / Patrick J. Loll
Chapter Two: X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels / Qiang Chen, Yan Xu, Pei Tang
Chapter Three: Solution NMR Studies of Anesthetic Interactions with Ion Channels / Vasyl Bondarenko, Marta Wells, Yan Xu, Pei Tang
Chapter Four: Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion Channels / J. Kent Blasie
Chapter Five: Fluorescent Anesthetics / Daniel J. Emerson, Ivan J. Dmochowski
Chapter Six: Investigation of Anesthetic-Protein Interactions by a Thermodynamic Approach / Hasan Babazada, Renyu Liu
Chapter Seven: Electron Spin Resonance (EPR) in Drosophila and General Anesthesia / Luca Turin, Efthimios M.C. Skoulakis
Chapter Eight: Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability / Zoe Gerstle, Rohan Desai, Sarah L. Veatch
Chapter Nine: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs / Megan McGrath, Douglas E. Raines
Chapter Ten: Optoanesthesia: Use of Anesthetic Photolabels In Vivo / Andrew R. McKinstry-Wu, Max B. Kelz
Chapter Eleven: Optogenetics and Chemogenetics / Ksenia Vlasov, Christa J. Van Dort, Ken Solt
Chapter Twelve: Genetic Reporters of Neuronal Activity: c-Fos and G-CaMP6 / Andrew E. Hudson
Chapter Thirteen: Genomics and Proteomic Techniques / Jonathan Z. Pan
Chapter Fourteen: Neurochemistry of Anesthetic States / Ralph Lydic, Helen A. Baghdoyan, Amanda L. May
Chapter Fifteen: Brief Introduction to Electroencephalography / Alex Proekt
Chapter Sixteen: Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities / Harry Scheinin, Emilee C. Alkire, Annalotta Scheinin, Michael T. Alkire, Oskari Kantonen, and Jaakko Långsjö
Chapter Seventeen: Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging / Simrun Chahal, Braedan R.J. Prete, Alanna Wade, Francis T. Hane, and Mitchell S. Albert.
Part A (v.602), part B (v.603).
Includes bibliographical references.
Eckenhoff, Roderic G., editor.
Dmochowski, Ivan J., editor.
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