Franklin

The Blood Brain Barrier and Inflammation [electronic resource] / edited by Ruth Lyck, Gaby Enzmann.

Publication:
Cham : Springer International Publishing : Imprint: Springer, 2017.
Series:
PIR (Series)
Progress in Inflammation Research
Format/Description:
Book
1 online resource (VI, 286 pages 32 illustrations, 24 illustrations in color.)
Subjects:
Medicine.
Immunology.
Neurosciences.
Infectious diseases.
Cytokines.
Growth factors.
Cell membranes.
Local subjects:
Biomedicine.
Immunology.
Neurosciences.
Membrane Biology.
Infectious Diseases.
Cytokines and Growth Factors.
System Details:
text file PDF
Summary:
Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
Contents:
General Introduction to Barrier Mechanisms in the Central Nervous System
Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research
The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions
Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases
Leakage at Blood-neural Barriers
Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology
MicroRNAs in Brain Endothelium and Inflammation
Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases
Pathways Across the Blood Brain Barrier
Neuroinflammation in Bacterial Meningitis
Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
Contributor:
Lyck, Ruth. editor.
Enzmann, Gaby. editor.
SpringerLink (Online service)
Contained In:
Springer eBooks
Other format:
Printed edition:
ISBN:
9783319455143
Publisher Number:
10.1007/978-3-319-45514-3 doi
Access Restriction:
Restricted for use by site license.
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