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Hemostasis and Thrombosis [electronic resource] : Methods and Protocols / edited by Emmanuel J. Favaloro, Giuseppe Lippi.

Publication:
New York, NY : Springer New York : Imprint: Humana Press, 2017.
Format/Description:
Book
1 online resource (XV, 565 pages) : 93 illustrations, 49 illustrations in color.
Series:
Methods in molecular biology 1064-3745 ; 1646
Methods in Molecular Biology, 1064-3745 ; 1646
Contained In:
Springer eBooks
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Subjects:
Medicine.
Molecular biology.
Local subjects:
Biomedicine. (search)
Molecular Medicine. (search)
System Details:
text file PDF
Summary:
This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.
Contents:
Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders
Preanalytical Issues in Hemostasis and Thrombosis Testing
The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing
Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR)
Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants
Performance and Interpretation of Mixing Tests in Coagulation
D-Dimer Testing: Laboratory Aspects and Current Issues
Determination of Fibrinogen and Thrombin Time (TT)
An Overview of Thrombophilia and Associated Laboratory Testing
Laboratory Testing for Activated Protein C Resistance (APCR)
Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing
Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing
Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing
Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT)
Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT)
Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies
Solid Phase Immunoassay for the Detection of Anti-β2 Glycoprotein I Antibodies
Measuring Direct Oral Anticoagulants
Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing
One-Stage Factor VIII Assays
Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A
Assessment of Factor XIII
Detection and Measurement of Factor Inhibitors
Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages and Disadvantages
Platelet Function Analyzed by Light Transmission Aggregometry
Whole Blood Platelet Aggregometry
Assessment of Platelet Function in Whole Blood by Flow Cytometry
Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood
Diagnosis or Exclusion of Von Willebrand Disease Using Laboratory Testing
Laboratory Testing for Von Willebrand Factor Antigen (VWF:Ag)
Laboratory Testing for Von Willebrand Factor Collagen Binding (VWF:CB)
Laboratory Testing for Von Willebrand Factor Ristocetin Cofactor (VWF:RCo)
Laboratory Testing for Von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb)
Laboratory Testing for Von Willebrand Factor Factor VIII Binding (for 2N VWD)
Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies
Laboratory Testing for Von Willebrand Factor Multimers
Thrombin Generation Assays (TGA)
The Overall Haemostatic Potential (OHP) Assay
Thromboelastography (TEG)
Post-Analytical Issues in Hemostasis and Thrombosis Testing.
Contributor:
Favaloro, Emmanuel J. editor.
Lippi, Giuseppe. editor.
SpringerLink (Online service)
Other format:
Printed edition:
ISBN:
9781493971961
Publisher Number:
10.1007/978-1-4939-7196-1 doi
Access Restriction:
Restricted for use by site license.