Franklin

Protein-Protein and Domain-Domain Interactions / by Pandjassarame Kangueane, Christina Nilofer.

Author/Creator:
Kangueane, Pandjassarame author.
Publication:
Singapore : Springer Singapore : Imprint: Springer, 2018.
Format/Description:
Book
1 online resource (XIX, 207 pages) : 161 illustrations, 82 illustrations in color.
Contained In:
Springer eBooks
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Details

Subjects:
Medicine.
Medical genetics.
Vaccines.
Bioinformatics.
Proteins.
Local subjects:
Biomedicine. (search)
Gene Function. (search)
Computational Biology/Bioinformatics. (search)
Protein Science. (search)
Vaccine. (search)
System Details:
text file PDF
Summary:
This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
Contents:
Module 1. Preface
Module 2. Introduction to protein complexes
Module 3. Historical advancement
Module 4. Databases for protein complexes
Module 5. Types of protein complexes
Module 6. Hetero dimer protein complexes
Module 7. Homo dimer protein complexes
Module 8. Multimer protein complexes
Module 9. Interfaces in protein complexes
Module 10. Principles of protein-protein binding
Module 11. Homodimer folding and binding
Module 12. Gene fusion and protein complexes
Module 13. Domain-domain interactions
Module 14. Protein docking: Methods, software tools and servers
Module 15. Protein complexes, pathways and networks
Module 16. Protein complexes and biological functions
Module 17. Protein complexes in diseases
Module 18. Protein complexes in drug discovery and vaccine development
Module 19. Protein complexes in genome and proteome analysis
Module 20. Conclusions and challenges.
Contributor:
Nilofer, Christina. author.
SpringerLink (Online service)
Other format:
Printed edition:
ISBN:
9789811073472
Publisher Number:
10.1007/978-981-10-7347-2 doi
Access Restriction:
Restricted for use by site license.