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Systemic Lupus Erythematosus [electronic resource] : Methods and Protocols / edited by Paul Eggleton, Frank J. Ward.

Publication:
New York, NY : Springer New York : Imprint: Humana Press, 2014.
Format/Description:
Book
1 online resource (XVII, 263 pages) : 35 illustrations, 22 illustrations in color.
Series:
Methods in Molecular Biology, Methods and Protocols, 1064-3745 ; 1134
Springer Protocols (Springer-12345)
Methods in Molecular Biology, Methods and Protocols, 1064-3745 ; 1134
Contained In:
Springer eBooks
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Subjects:
Medicine.
Immunology.
Pathology.
Local subjects:
Biomedicine. (search)
Immunology. (search)
Pathology. (search)
System Details:
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Summary:
Systemic Lupus Erythematosus: Methods and Protocols describes a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system, and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.   Authoritative and practical, Systemic Lupus Erythematosus: Methods and Protocols  appeals to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.
Contents:
Pathology of Systemic Lupus Erythematosus - The Challenges Ahead
The Lupus Biomarker Odyssey: One Experience
Detection of Anti Nuclear Antibodies in SLE
Tests for Circulating Immune Complexes
Methods for Measuring Antibody Dependent Cell-Mediated Cytotoxicity in vitro
Recombinant Antibody Microarray for Profiling the Serum Proteome of SLE
Bi-functional Antibody Fragment-based Fusion Proteins for the Targeted Elimination of Pathogenic T-cell Subsets
TLC Immunostaining for Detection of "Anti-Phospholipid" Antibodies
Induced Murine Models of Systemic Lupus Erythematosus
Measuring Interferon Alpha and other Cytokines in SLE
Detection of SLE antigens in Neutrophils Extracellular Traps (NETs)
Detection and Characterization of Autoantibodies Against Modified Self-proteins in SLE Sera after Exposure to Reactive Oxygen and Nitrogen Species
Generation of Self-peptides to Treat Systemic Lupus Erythematosus
Measurement of Malondialdehyde, Glutathione and Glutathione Peroxidase in SLE Patients
Evaluating a Particular Circulating MicroRNA Species from an SLE Patient using Stem Loop qRT-PCR
Microarray Technology for Analysis of MicroRNA Expression in Renal Biopsies of Lupus Nephritis Patients. Laboratory Tests for the Antiphospholipid Syndrome
Isolation, Polarisation and Expansion of CD4+ T Helper Cell Lines and Clones using Magnetic Beads
Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus.
Contributor:
Eggleton, Paul. editor.
Ward, Frank J. editor.
SpringerLink (Online service)
Other format:
Printed edition:
ISBN:
9781493903269
Publisher Number:
10.1007/978-1-4939-0326-9 doi
Access Restriction:
Restricted for use by site license.