Microfluidics and nanotechnology : biosensing to the single molecule limit / edited by Eric Lagally, Western Govenors University ; managing editor, Krzysztof Iniewski, CMOS Emerging Technologies Research Incorporated, Vancouver, British Columbia, Cana
- 1st edition
- Boca Raton : Taylor & Francis, 
- Devices, Circuits, and Systems
Devices, Circuits, and Systems
1 online resource (284 p.)
- Biosensors -- Industrial applications.
- Medical subjects:
- Molecular Probe Techniques.
Natural Science Disciplines.
Technology, Industry, and Agriculture.
- Local subjects:
- Biomolecules. (search)
Microfluidics -- Industrial applications. (search)
Molecular recognition. (search)
- Electronic books.
- System Details:
- text file
- Preface Microtechnology and more recent nanotechnology methods have enabled the fabrication of a wide variety of new chemical and biological sensors. These sensors demonstrate exquisite sensitivity and low limits of detection, enabling exploration of new scientific frontiers. In particular, the novel physics that emerges at small length scales allows parallel, mass-fabricated sensors for detection to both single-cell and single-molecule limits. Stochastic differences between individual cells and molecules have been shown to play important roles in larger biological systems, and these novel sensors have begun to test and elucidate these effects. This book focuses on the combination of soft materials like elastomers and other polymers with materials like semiconductors, metals, and glass to form integrated detection systems for biological and chemical targets. Microfluidic advances in this arena include systems for forming and analyzing tiny droplets (so-called droplet microfluidics); the combination of electrostatic and dielectrics to manipulate droplets on the microscale; miniaturized separation systems, including electrophoresis, for detecting a wide range of genetic targets from single cells; and novel optical and mechanical detection methods at the single-cell and single-molecule scales. This book represents a snapshot of the state of the art from the world's leading microfluidics and nanotechnology laboratories. The combination of different materials at both of these length scales is driving a powerful new set of scientific inquiries that have to date been impossible to address using other technologies. The book is arranged in two major sections. In Part I, the authors discuss a number of unique detection technologies-- Provided by publisher.
- Front Cover; Contents; Preface; Editors; Contributors; Chapter 1: Toward Unsupervised Smart Chemical Sensor Arrays; Chapter 2: Active CMOS Biochip for Electrochemical DNA Assays; Chapter 3: Label-Free DNA Sensor Based on a Surface Long-Period Grating; Chapter 4: Measuring the Physical Properties of Cells; Chapter 5: Technologies for Low-Cost, Hall Effect-Based Magnetic Immunosensors; Chapter 6: Two-Dimensional Paper Networks for Automated Multistep Processes in Point-of-Care Diagnostics; Chapter 7: Droplet-Based Digital Microfluidics for Single-Cell Genetic Analysis
Chapter 8: Droplet-Based Microfluidics for Biological Sample Preparation and AnalysisChapter 9: A Review of Tubeless Microfluidic Devices; Back Cover
- Description based upon print version of record.
Includes bibliographical references.
- Lagally, Eric, editor.
Iniewski, Krzysztof, editor.
- Publisher Number:
- 10.1201/b17020 doi
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