"The occurrence of personality, sensory and cognitive disturbances after anesthesia and surgery has been recognized for many decades, although the magnitude, duration and causes have remained a matter of debate. Certainly the transient occurrence of delirium after surgery is well known, and the various forms are reviewed here by Drs. Proekt, Gabbard, Sieber and Oh. The more durable forms of cognitive impairment after surgery have been more enigmatic. In the past two decades, the application of strict neurocognitive testing by research groups have definitively documented impairments lasting from weeks to months, and thus a term was coined; post-operative cognitive dysfunction" or POCD, a "syndrome" reviewed in depth here by Drs. Nelli, Culley and Crosby. Complicating the analysis of POCD has been the fact that a large number of patients may actually have cognitive improvement as a result of enhanced mobility after orthopedic surgery or reduced pain perhaps following cancer resection. Thus, post-operative cognitive improvement (POCI) is reviewed here by Drs. Arias, Sibille and Price Completing the first section of this book is the more contentious, but critically important topic of whether anesthesia and surgery result in a persistent cognitive disorder, such as mild cognitive impairment or dementia, an area discussed in detail by Drs. Schenning and Hogan"--Provided by publisher.
Machine generated contents note: Section 1. Cognitive Function in Perioperative Care: 1. Emergence Delirium: A New Hypothesis for an Old Problem Alexander Proekt; 2. Postoperative Delirium Jennifer Gabbard, Frederick E Sieber, and Esther S Oh; 3. Postoperative Cognitive Dysfunction: An Overview Jennifer Nelli, Deborah J. Culley, and Gregory Crosby; 4. Postoperative Cognitive Improvement Franchesca Arias, Kimberly T. Sibille, and Catherine C. Price; 5. Persistent Perioperative Neurocognitive Disorder: Does Surgery Accelerate Dementia? Katie J Schenning and Kirk J Hogan; Section 2. Pathophysiology of the Perioperative Neurocognitive Disorders: 6. Animal Models and Cognitive Testing of Perioperative Neurocognitive Disorder Maryellen F. Eckenhoff and Colm Cunningham; 7. Anaesthesia and neurodegeneration Phillip Vlisides and Zhongcong Xie; 8. Pharmacologic (Receptor-Based) Mechanisms of Postoperative Cognitive Dysfunction Lauren G. Powlovich and Zhiyi Zuo; 9. Surgery and the Inflammatory Response Azeem Alam and Daqing Ma; 10. Comorbidities and Prolonged Cognitive Decline Mervyn Maze and Xiaomei Feng; Section 3. Symptomatology and Diagnosis for the Perioperative Neurocognitive Disorders: 11. Cognitive Testing for Perioperative Neurocognitive Disorder Lisbeth Evered; 12. Biomarkers of Postoperative Cognitive Dysfunction: Finding the Signal Amidst the Noise Miles Berger, S. Kendall Smith, and Anver Khan; 13. Neuroimaging in the Perioperative Neurocognitive Disorders James W. Ibinson; Section 4. Clinical Recommendations and Prevention: 14. Preoperative Testing to Identify Vulnerable Subgroups Deborah J. Culley; 15. Informed Consent and Cognitive Impairment Brendan Silbert and David A. Scott; 16. Perioperative Neurocognitive Disorder Mitigation Strategies Roderic G. Eckenhoff and Niccol- Terrando.