Epigenetics and regeneration / Daniela Palacios.

Author/Creator:

Palacios, Daniela author.

Edition:

First edition.

Publication:

London : Academic Press, 2019.

Series:

Translational epigenetics series; v. 11.
Translational epigenetics series ; v. 11

Format/Description:

Book
1 online resource.

Subjects:

Epigenetics.
Regeneration (Biology)

Medical subjects:

Epigenomics.

Form/Genre:

Electronic books.
Electronic books.

Contents:

Front Cover; Epigenetics and Regeneration; Copyright; Contents; Contributors; Chapter 1: Epigenetics and Regeneration: An Overview; 1.1. Introduction; 1.2. Epigenetic Regulation of Gene Expression and Cell Fate; 1.3. Development, Reprogramming, and Tissue Regeneration: From the Zygote to Emerging Sources of Multipotent Cells for Re ...; 1.4. The Epigenetics of Tissue Development, Homeostasis, and Regeneration; 1.5. Epigenetics and Environment: How Age, Environmental Cues, and Epigenetic Drugs Influence The Capability of Stem Cell ...
1.6. Conclusions: Is There a Place for Epigenetics in Regenerative Medicine?Acknowledgments; List of Abbreviations; References; Section I: Epigenetics: Molecular Players and Mechanisms; Chapter 2: Dynamics and Mechanisms of DNA Methylation Reprogramming; 2.1. Introduction; 2.2. DNA Methylation Machinery; 2.3. DNA Demethylation; 2.4. DNA Methylation in Early Development; 2.5. How Necessary is DNA Methylation Reprogramming for Early Development?; 2.6. DNA Methylation Trajectories During Reprogramming of Somatic Cells; 2.7. 6-Methyldeoxyadenosine in Mammalian DNA?; 2.8. Future Perspectives
AcknowledgmentsReferences; Chapter 3: Histone Modifications; 3.1. Epigenetics and Chromatin Dynamics; 3.2. Histone Modifications; 3.2.1. Histone Lysine Acetylation; 3.2.2. Histone Lysine Methylation; 3.2.3. Histone Lysine Methylation in Transcription; 3.2.3.1. Gene silencing by histone H3 lysine 9 and lysine 27 methylation; 3.2.3.2. Gene activation by H3 lysine 4 and H3 lysine 36 methylation; 3.2.4. Histone Arginine Methylation; 3.2.5. Histone Phosphorylation; 3.2.6. Histone Ubiquitination; 3.2.7. Histone Sumoylation; 3.2.8. Histone Glycosylation; 3.2.9. Histone Poly-ADP Ribosylation
3.3. The Histone Code3.3.1. Bivalent Domains, Promoters, and Enhancers; 3.3.2. Histone Modifications and Nuclear Organization; 3.4. Histone Modifications in Cell Fate Changes and Cell Differentiation; 3.4.1. Histone Modifications as Regulators of Neuronal Development and Function; 3.4.2. Histone Mutations in Disease: The Example of Histone Gene Mutations in Brain Tumors; 3.4.3. Histone Modifications in Skeletal Muscle Differentiation and Regeneration; 3.5. Conclusions and Perspectives; List of Abbreviations; References
Chapter 4: Noncoding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation4.1. Introduction; 4.1.1. Classification and Mechanisms of Action; 4.2. The Role of miRNAs in Pluripotency; 4.2.1. miRNAs as Regulators of the Cell Cycle and Apoptosis of Embryonic Stem Cells (ESCs); 4.2.2. miRNAs Regulating the Maintenance of Self-Renewal and Pluripotency of ESCs; 4.2.3. miRNAs in Somatic Cell Reprogramming Towards iPSCs; 4.3. miRNAs as Regulators of Cell Fate and Cell Differentiation; 4.3.1. miRNAs and Regulation of Muscle Differentiation

Notes:

Includes index.
Includes bibliographical references and index.
Online resource; title from PDF title page (EBSCO, viewed June 3, 2019).

ISBN:

9780128148808
0128148802
9780128148792

OCLC:

1102638945

Access Restriction:

Restricted for use by site license.

Online:

Connect to full text
http://hdl.library.upenn.edu/1017.12/2471224

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