Studies on Psychiatric Disorders / edited by Anna Dietrich-Muszalska, Ved Chauhan, Sylvain Grignon.

New York, NY : Springer New York : Imprint: Humana, 2015.
1 online resource (XX, 596 pages) : 31 illustrations, 17 illustrations in color.
1st ed. 2015.
Biomedical and Life Sciences (Springer-11642)
Oxidative stress in applied basic research and clinical practice 2197-7224
Oxidative Stress in Applied Basic Research and Clinical Practice, 2197-7224
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Oxidative stress.
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This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories. Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants-in particular polyphenols, ω-3 fatty acids or combination of both-could be effective for long-term treatment of some neuropsychiatric disorders.
1. Oxidative nitrative and chlorinative stress: biomarkers
Part 1. Clinical aspects
2. Oxidative stress in schizophrenia
3. Oxidative stress in bipolar disorders
4. Contribution of oxidative stress to the pathophysiology of autism spectrum disorders: Impact of genetic and environmental factors
5. Oxidative stress and anxiety disorder
6. The relationship between oxidative stress and obsessive- compulsive disorder
7. A relationship between oxidative status and attention deficit hyperactivity disorder
8. The role of oxidative stress in neurodegenerative diseases
Part 2. Pathophysiological aspects
9. Magnetic resonance spectroscopy studies in Bipolar Disorder patients: Focus on the potential role of oxidative stress
10. The impact of oxidative stress on dopaminergic neurotransmission
11. The reciprocal effects of oxidative stress and glutamate neurotransmission
12. Mitochondrial dysfunction in psychiatric disorders
13. The kynurenine pathway at the interface between neuroinflammation, oxidative stress and neurochemical disturbances: Emphasis in schizophrenia
14. Dysregulation of glutathione synthesis in psychiatric disorders
15. Role of nitrative stress in brain of schizophrenic patients
16. Blood platelet as a peripheral cell in oxidative stress in psychiatric diseases
17. Mitochondrial dysfunction in autism
18. Ultrasound and Autism: How Disrupted Redox Homeostasis and Transient Membrane Porosity Confer Risk
19. Animal Model of Autistic Regression: Link to Toxicant-Induced Oxidative Stress
20. Genetic Polymorphism Related to Oxidative Stress in Autism
21. Telomere length in major psychiatric disorders. Is there any relationship between telomere length and oxidative stress?
22. The impact of oxidative stress on GAD67 levels and parvalbumin - positive neurons
23. The possible role of iron in neurodegeneration
24. Oxidation stress and polyunsaturated lipid peroxidation products in the CNS: focus on DHA-derived fragment
Part 3. Therapeutic aspects
25. Antioxidant interventions in neuropsychiatric disorders
26. Antioxidant plant polyphenols and cognitive disorders
27. Hyperbaric oxygen treatment in autism spectrum disorders
28. Effects of lithium on oxidative stress
29. Cryostimulation as adjunct treatment in psychiatric disorders
Dietrich-Muszalska, Anna, editor., Editor,
Chauhan, Ved, editor., Editor,
Grignon, Sylvain, editor., Editor,
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10.1007/978-1-4939-0440-2 doi
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