Franklin

The genetic basis of kidney cancer / W. Marston Linehan.

Author/Creator:
Linehan, Marston (National Institutes of Health, USA) author,
Publication:
London : Henry Stewart Talks, 2014.
Format/Description:
Video
1 online resource (1 streaming video file (52 min.)) : color, sound.
Series:
Henry Stewart talks. Biomedical & life sciences collection. Kidney in health and disease.
Henry Stewart talks. Biomedical & life sciences collection. Molecular genetics of human disease.
Molecular genetics of human disease, 2056-452X
The kidney in health and disease, 2056-452X
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Subjects:
Cancer -- Genetic aspects.
Kidneys -- Cancer.
Kidneys -- Diseases -- Genetic aspects.
Medical genetics.
Renal cell carcinoma.
Medical subjects:
Carcinoma, Renal Cell.
Genetics, Medical.
Kidney Diseases -- genetics.
Kidney Neoplasms.
Metabolic Diseases.
System Details:
Mode of access: World Wide Web.
Contents:
Contents: Renal carcinoma
Stage I , Stage IV Kidney Cancer
Human renal epithelial neoplasms
Loss of alleles in Renal Cell Carcinoma
Mapping the minimal 3p loss region in Clear Cell Renal Carcinoma
Studying cancer families to identify renal carcinoma genes
Identification of kidney cancer genes
Inherited forms of renal carcinoma
Clear cell Renal Carcinoma: von Hippel Lindau (VHL)
VHL gene
VHL gene localization map
Germline VHL mutations
Papillary Renal Carcinoma
Mouse studies of VHL gene
VHL gene function
HIFα
Downstream effects of VHL mutation
Targeting VHL/HIF in Clear Cell RCC
TCGA Clear Cell Kidney Cancer
Intratumor heterogeneity
Warburg effect in Clear Cell Kidney Cancer
Non-Clear Cell RCC
Locally advanced Kidney Cancer
Hereditary Papillary Renal Carcinoma (HPRC)
Inherited Renal Carcinoma
Type 1 Papillary Renal Carcinoma
Penetrance of MET mutation H1210R
MET gene: Type 1 Papillary RCC
Location of the HPRC gene
HPRC: Activating mutations in the Tyrosine Kinase domain of MET
Location of MET mutations in the HPRC patients
Targeting MET RCC gene pathway
Potential small molecule target: MET Tyrosine Kinase inhibition
Foretinib: Dual VEGFR and MET Inhibitor
MiT Kidney Cancer TFE3, TFEB, MITF
UOK124, Papillary Kidney Cancer
UOK124, UOK120, UOK 146 and TFE3 Kidney Cancer
Inherited Renal Carcinoma Birt-Hogg-Dubé (BHD)
Birt Hogg Dubé cutaneous manifestations
Kidney tumors in BHD
BHD renal tumor pathology
BHD lung cysts
Identification of the BHD Gene
Cutaneous Fibrofolliculomas
BHD Gene: Chromophobe RCC
BHD Gene Locus: Chromosome 17
BHD Protein Sequence
FLCN Mutation Spectrum
Therapeutic Approach: What Kind of Gene is FLCN?
BHD Gene Analysis in BHD-Associated RCC
Somatic mutations in renal Tumors from BHD patients
UOK 257, BHD -/- RCC cell line study
How does the FLCN gene function?
Folliculin-FNIP1/2-AMPK interactions
mTORC1/mTORC2 activation: FLCN-deficient Kidney Cancer
BHD deletion specifically in the kidney
BHDf/d/KSPCre mouse kidney study
Hereditary Leiomyomatosis Renal Cell Carcinoma (HLRCC)
HLRCC: cutaneous manifestations, Uterine Leiomyomas
HLRCC: Papillary Kidney Cancer Type 2
Orangophilic nucleoli + Perinucleolar halos
Fumarate Hydratase gene: HLRCC
UOK-262 study
Loss of a Krebs Cycle Enzyme can lead to Kidney Cancer
Impaired citric acid cycle and "Warburg effect"
HLRCC-Renal Cancer: glucose-dependent
PET scan
HLRCC novel treatment approaches
Kidney cancer: a metabolic disease.
Notes:
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Publisher Number:
3817 Henry Stewart Talks
Access Restriction:
Restricted for use by site license.