Franklin

Germline pharmacogenomics as a tool to individualize therapy in breast cancer / David A. Flockhart.

Author/Creator:
Flockhart, David A. , author
Publication:
London : Henry Stewart Talks, 2009.
Format/Description:
Video
1 online resource (1 streaming video file (43 min.)) : color, sound.
Series:
Henry Stewart talks. Biomedical & life sciences collection. Cancer therapy : latest thinking in efficacy and toxicity.
Cancer therapy : latest thinking in efficacy and toxicity, 2056-452X
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Details

Medical subjects:
Breast Neoplasms -- drug therapy.
Breast Neoplasms -- genetics.
Neoplasms -- complications.
Neoplasms -- therapy.
System Details:
Mode of access: World Wide Web.
Contents:
Contents: Major clinical issues in the personalized treatment of breast cancer
The efficacy barrier: tamoxifen and anastrozole
Advances in targeting that have improved the treatment of breast cancer
Tumor-based expression arrays
Prognostic expression arrays remain valuable beyond tumor grade and stage
Pharmacogenetic principles
Principles for valuable predictive biomarkers
COBRA
Anti-estrogen therapy for breast cancer
The ELPH trial
Aromatase inhibitor side effects in the ELPH trial
The problem with aromatase inhibitors in Asia
Breast cancer around the world
Classic understanding of tamoxifen pharmacology
Tamoxifen metabolism
Endoxifen
Serum concentrations of tamoxifen and metabolites predict efficacy
CYP2D6
Relapse-free survival was worse in poor metabolizers
Clinical consequences
Pharmacodynamic pharmacogenomics
Multiple targets to inhibit angiogenesis
Bevacizumab in breast cancer.
Notes:
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Publisher Number:
2175 Henry Stewart Talks
Access Restriction:
Restricted for use by site license.