Franklin

The pRB/E2F pathway / Jacqueline Lees.

Author/Creator:
Lees, Jacqueline. , author
Publication:
London : Henry Stewart Talks, 2009.
Format/Description:
Video
1 online resource (1 streaming video file (33 min.)) : color, sound.
Series:
Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.
The cell division cycle : controlling when and where cells divide and differentiate, 2056-452X
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Details

Medical subjects:
Cell Cycle Proteins.
System Details:
Mode of access: World Wide Web.
Contents:
Contents: The E2F transcription factors control cell cycle entry
The pRB/E2F pathway
pRB and E2F are both families of proteins
Differential roles of the pocket proteins
Repression and activation of E2F target genes is regulated by distinct E2F complexes
Rb mutant mice
Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity
The activating E2Fs can also induce apoptosis and senescence genes in tumor cells
Role of pRB-E2F in DNA damage response
pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.
Notes:
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Publisher Number:
2338 Henry Stewart Talks
Access Restriction:
Restricted for use by site license.