Physics of cancer. Volume 1, Interplay between tumor biology, inflammation and cell mechanics / Claudia Tanja Mierke.

Mierke, Claudia Tanja author.
Other Title:
Interplay between tumor biology, inflammation and cell mechanics.
Second edition.
Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2018]
IOP (Series). Release 5.
IOP expanding physics
Biophysical Society series.
[IOP release 5]
IOP expanding physics, 2053-2563
Biophysical Society series
1 online resource (various pagings) : illustrations (chiefly color)
Pathology, Molecular.
Cancer cells -- Mechanical properties.
Medical subjects:
Cell Transformation, Neoplastic.
Cell Physiological Phenomena.
Tumor Microenvironment.
Biomechanical Phenomena.
System Details:
Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
Claudia Tanja Mierke has a background in biology and molecular oncology and is head of the biological physics division at the University of Leipzig where she regularly teaches molecular and cell biology, biophysics and soft matter physics to physicists. She is concerned with various research areas developing our understanding of the physical aspects of cancer.
In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer. This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion
part I. Introduction to tumor biology from a biophysical point of view
1. Initiation of a neoplasm or tumor
1.1. Initiation of a neoplasm, tumor growth and neoangiogenesis
1.2. Malignant progression of cancer (metastasis)
1.3. Hallmarks of cancer
1.4. The impact of the mechanical properties of cancer cells on their migration
2. Inflammation and cancer
2.1. Inflammation : acute and chronic
2.2. The dual relationship between inflammation and cancer
part II. The role of the mechanical properties of cancer cells in cellular invasion. 3. Cellular stiffness and deformability
3.1. How can cellular stiffness and the deformability of cells be measured?
3.2. Magnetic tweezers
3.3. Optical cell stretcher
3.4. Optical tweezers
3.5. Microfluidic filtration and mechanical deformability
3.6. Real-time deformation cytometry
4. Cell-cell and cell-matrix adhesion strength, local cell stiffness and forces
4.1. Atomic force microscopy
4.2. Traction forces
4.3. Lipid drops as stress sensors
4.4. Dual micropipette aspiration (DPA)
4.5. Förster resonance energy transfer (FRET)-based molecular tension sensors
5. Cell surface tension, the mobility of cell surface receptors and their location in specific regions
5.1. Surface tension
5.2. The mobility of surface receptors
5.3. Specific membrane regions as a location for surface receptors
5.4. Role of the cortex confinement on membrane diffusion
6. Cytoskeletal remodeling dynamics
6.1. Cytoskeletal remodeling dynamics within unperturbed cells
6.2. Cytoskeletal remodeling dynamics upon mechanical stretching
6.3. Dynamic cell-level responses derive from local physical cues
6.4. Cytoskeletal dynamics in 3D differ from those observed in 2D
6.5. Nano-scale particle tracking
6.6. FRAP
part III. The role of actin filaments and intermediate filaments during cell invasion. 7. Role of the actin cytoskeleton during matrix invasion
7.1. The actin cell cytoskeleton
7.2. The actin monomer
7.3. The actin filaments and polymerization
7.4. Actin structures : protrusions and cell-cell junctions
7.5. Does so-called 'cortical actin' and an actin cortex exist?
7.6. The different stress-fiber types
7.7. Actin-myosin interaction during cell migration
7.8. The effect of actin-bunding proteins on cell migration and invasion
7.9. The actin-binding proteins
7.10. Actin-binding domains and their roles in de novo actin polymerization
7.11. Microscopic visualization of F-actin in fixed cells and tissue samples
7.12. Microscopic visualization of F-actin for live-cell-imaging during migration and invasion of cells
8. Intermediate filaments and nuclear deformability during matrix invasion
8.1. Structure and assembly of intermediate filaments
8.2. Involvement of intermediate filaments in vesicular trafficking
8.3. Intermediate filaments play a crucial role in cellular mechanical properties and cellular motility
8.4. Viscoelasticity of purified intermediate filaments in vitro
8.5. Functional role of intermediate filaments in mechanotransduction processes
8.6. The role of intermediate and actin filament interactions
8.7. The role of vimentin as a promotor of cell migration during cancer progression
8.8. The impact of keratins 8/18 on epithelial cell migration
8.9. Interaction between filamin A and vimentin in cellular motility
8.10. The role of nuclear intermediate filaments in cell invasion
8.11. The role of cell division in cellular motility.
"Version: 20181001"--Title page verso.
Includes bibliographical references.
Title from PDF title page (viewed on November 8, 2018).
Institute of Physics (Great Britain), publisher.
Other format:
Print version:
Publisher Number:
10.1088/978-0-7503-1753-5 doi
Access Restriction:
Restricted for use by site license.
Location Notes Your Loan Policy
Description Status Barcode Your Loan Policy