Franklin

The illusion of evidence-based medicine : exposing the crisis of credibility in clinical research / Jon Jureidini and Leemon B. McHenry.

Author/Creator:
Jureidini, Jon, author.
Publication:
Mile End, South Australia : Wakefield Press, 2020.
Format/Description:
Book
318 pages ; 24 cm
Subjects:
Evidence-based medicine.
Clinical medicine.
Pharmaceutical industry.
Medical ethics.
Clinical trials.
Conflict of interests.
Medical subjects:
Evidence-Based Medicine.
Clinical Medicine.
Drug Industry.
Ethics, Medical.
Summary:
An expose of the corruption of medicine by the pharmaceutical industry at every level, from exploiting the vulnerable destitute for drug testing, through manipulation of research data, to disease mongering and promoting drugs that do more harm than good. Authors, Professor Jon Jureidini and Dr Leemon McHenry, made critical contributions to exposing the scientific misconduct in two infamous trials of antidepressants. Ghostwritten publications of these trials were highly influential in prescriptions of paroxetine (Paxil) and citalopram (Celexa) in paediatric and adolescent depression, yet both trials (Glaxo Smith Kline's paroxetine study 329 and Forest Laboratories' citalopram study CIT-MD-18) seriously misrepresented the efficacy and safety data. The Illusion of Evidence-Based Medicine provides a detailed account of these studies and argues that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry. Without a basis for independent evaluation of the results of randomised, placebo-controlled clinical trials, there can be no confidence in evidence-based medicine. Science demands rigorous, critical examination and especially severe testing of hypotheses to function properly, but this is exactly what is lacking in academic medicine.
Contents:
The crisis of credibility in clinical research
the corruption of clinical research: Study 329 and Study CIT-MD-18
a rigorous conception of science in medicine
communication of scientific findings
academics and the corporate university
distorted research priorities
regulators and governance
solutions.
Notes:
Includes bibliographical references and index.
Contributor:
McHenry, Leemon B., 1950- author.
ISBN:
9781743057247
1743057245
OCLC:
1151900246
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