Franklin

Drug delivery aspects. Volume 4, Expectations and realities of multifunctional drug delivery systems edited by Ranjita Shegokar.

Other Title:
Expectations and realities of multifunctional drug delivery systems
Publication:
[S.l.] : Academic Press, 2020.
Series:
EXPECTATIONS AND REALITIES OF MULTIFUNCTIONAL DRUG DELIVERY SYSTEMS.4
Format/Description:
Book
1 online resource
Subjects:
Drug delivery systems.
Medical subjects:
Drug Delivery Systems.
Contents:
Intro
Drug Delivery Aspects: Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems
Copyright
Contents
Contributors
Preface
Chapter 1: Versatile hyaluronic acid nanoparticles for improved drug delivery
1. Introduction
2. Hyaluronic acid
2.1. Chemistry
2.2. Sources
2.3. Physiological role
2.4. Turnover and elimination pathways
3. Preparation of hyaluronic acid nanoparticles
3.1. Conjugate formation
3.2. Self-assemblies formation
3.3. Ionic nanocomplexes formation
3.4. Nanogels formation
4. Applications of HA nanoparticles
4.1. Skin applications
4.2. Osteoarthritis
4.3. Tissue engineering
4.4. Cancer targeting
4.5. Atherosclerosis
4.6. Ocular drug delivery
4.7. Insulin sensitivity and diabetes
4.8. Theranostic and imaging
5. Clinical status
6. Conclusion
References
Chapter 2: Preclinical testing-Understanding the basics first
1. Introduction
2. Preclinical studies
3. Regulatory aspects of preclinical studies
4. Preclinical testing and models used
4.1. In vitro assays/cell line assays
5. Animal models and type of tests
5.1. In vivo evaluation
5.2. Pharmacodynamics
5.3. Pharmacokinetic
5.4. Toxicology
5.5. Advances in the field
5.6. Databases
6. Conclusion
References
Chapter 3: Aqueous polymeric coatings: New opportunities in drug delivery systems
1. Introduction
2. Coating types and polymers used
2.1. Aqueous-based coatings for sustained drug release (cellulosic type)
2.1.1. Ethylcellulose
2.2. Aqueous-based coatings for enteric drug release
2.2.1. Cellulose acetate phthalate
2.2.2. Hydroxypropyl methylcellulose acetate
2.3. Acrylate-type aqueous-based coatings
2.3.1. Ammonio methacrylate copolymers
2.3.2. Ethyacrylate methylmethacrylate
2.3.3. Methacrylic acid copolymers for enteric drug release
2.4. Aqueous-based flexible polymer coatings for sustained drug release
2.4.1. Polyvinyl acetate
3. Strategies to improve storage stability
3.1. Optimization of curing conditions
3.2. Plasticizer type and content
3.3. Addition of high Tg polymers
3.4. Addition of hydrophilic excipients
3.5. High solids content
4. Solidification of self-nanoemulsifying drug delivery systems by fluid bed coating
5. Conclusion
References
Chapter 4: Large-scale manufacturing of nanoparticles-An industrial outlook
1. Introduction
2. Nanosuspensions
2.1. Top-down approach
2.2. Bottom-up approach
2.3. Considerations on scale-up from lab to industrial scale
2.4. Large-scale manufacturing unit operation
3. Lipid nanoparticles
4. Nanoparticle characterization and analytical techniques used
4.1. Other characterizations
5. Conclusion
References
Chapter 5: The role of polymers and excipients in developing amorphous solid dispersions: An industrial perspective
1. Introduction
Notes:
Includes index.
Electronic reproduction. Amsterdam Available via World Wide Web.
Contributor:
Shegokar, Ranjita.
ScienceDirect (Online service)
ISBN:
9780128218501
0128218509
9780128212226
0128212225
Publisher Number:
99987485876
Access Restriction:
Restricted for use by site license.
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